Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine

Patel , Mohanakumara and Nambiar , Sreejayan and Priti, V and Ramesha, BT and Ravikanth, G and Ganeshaiah, KN and Vasudeva, R and Mohan, John and Thankayyan Retnabai , Santhoshkumar and Mishra, Prabhu Dutt and Viswakarma, Ram and Uma Shaanker, R (2010) Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine. Fitoterapia, 81 (2). pp. 145-148.

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Abstract

Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukinewas first reported fromAmoora rohituka (0.083% dryweight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from theWestern Ghats, India. Crude extracts of the treewere found to be highly effective against ovarian and breast cancer lines tested.

Item Type: Article
Additional Information: Copyright of this article belongs to Elsevier
Uncontrolled Keywords: Dysoxylum binectariferum Rohitukine Anticancer activity Flavopiridol
Subjects: C Publications by ATREEians > G Journal Papers
Divisions: Publications by ATREEians > Journal Papers
Depositing User: Users 12 not found.
Date Deposited: 17 Feb 2014 10:55
Last Modified: 08 Nov 2016 09:13
URI: http://eprints.atree.org/id/eprint/46

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